Free Printable WorksheetScienceGrade 10Science CurriculumBIO.10.60

10.60 Mutations Worksheet

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Worksheet Overview & Skills Covered

Core academic competencies and curriculum alignment

This Biology Science worksheet provides structured practice on 10.60 Mutations. Students are guided through targeted exercises that build foundational understanding, computational accuracy, and critical thinking skills.

Mutations: Students identify substitution, insertion, deletion, frameshift, silent, missense, and nonsense mutations and predict possible effects on protein and phenotype. Rigor range: standard concept checks through honors/Pre-AP/AP-ready sequence, probability, pedigree, population, and bioethics analysis. Aligned to FreeK12Practice High School Biology Curriculum Crosswalk (NGSS/NRC Framework; CCSS Literacy and Mathematics; AP Biology enrichment; Texas TEKS Biology; Florida NGSSS/CPALMS Biology; Virginia SOL Biology; California NGSS and New York State Science Learning Standards) BIO.10.60 - Mutations: National: NGSS HS-LS3-1; HS-LS3-2; DCI LS3.A, LS3.B; CCSS RST.9-10.7; HSS.CP.A.1; AP Biology IST-1, EVO-2. State frameworks: TX TEKS BIO.7C; FL NGSSS SC.912.L.16.4, SC.912.L.16.9; VA SOL BIO.5c, BIO.7b; CA NGSS/NYSSLS HS-LS3-1, HS-LS3-2.

Whether you are an educator preparing classroom handouts, a tutor reinforcing weekly topics, or a parent supporting homeschool learning, this printable resource gives students the deliberate practice required to achieve subject fluency and master state standards.

Grade

Biology

Subject

Science

Domain

Science Curriculum

Formats

PDF & DOCX

Sample Practice Problems

Preview the types of problems and questions covered in this worksheet

Below are sample questions representative of the exercises included on this worksheet and related 10.60 Mutations skill assessments:

Problem 1Difficulty: Mastery

A mutation changes an mRNA codon from UGG, which codes for tryptophan, to UGA, a stop codon. Later, a second mutation changes UGA to UGG in some cells. What best describes the second mutation?

AA frameshift that deletes one base

BA silent mutation because UGA and UGG are identical

CA germ-line mutation in every offspring

DA reversion that can restore the original codon in those cells

Solution & Explanation:Changing the mutant codon back to the original codon is a reversion and may restore protein sequence in those cells.

Problem 2Difficulty: Mastery

A variant table lists four changes in a gene linked to a disorder. Which variant is the strongest candidate for causing the disorder?

AA common silent variant found equally in affected and unaffected people

BA common intergenic variant with no expression effect

CA rare nonsense variant that appears in affected family members and not unaffected members

DA sequencing error seen in only one low-quality read

Solution & Explanation:A rare variant that disrupts protein and segregates with the phenotype is stronger evidence than common or low-quality findings.

Problem 3Difficulty: Mastery

A parent has no mutation detected in blood, but two children have the same new dominant mutation. Which explanation could account for this pattern?

AA silent mutation in the children's ribosomes

BGerm-line mosaicism in the parent

CA mutation that cannot be inherited

DA lack of DNA in gametes

Solution & Explanation:If some gamete-producing cells carry a mutation not found in blood, more than one child can inherit it.

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Frequently Asked Questions

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QWhat grade level and standards does this worksheet align with?

This worksheet is designed specifically for Biology Science students. It aligns with educational standard BIO.10.60 (National: NGSS HS-LS3-1; HS-LS3-2; DCI LS3.A, LS3.B; CCSS RST.9-10.7; HSS.CP.A.1; AP Biology IST-1, EVO-2. State frameworks: TX TEKS BIO.7C; FL NGSSS SC.912.L.16.4, SC.912.L.16.9; VA SOL BIO.5c, BIO.7b; CA NGSS/NYSSLS HS-LS3-1, HS-LS3-2.).