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Enzymes as Biological Catalysts
Grade Level
AP Biology
APB.163 Enzymes as Biological Catalysts
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A mutation makes an enzyme bind the substrate ground state more tightly but does not stabilize the transition state. Which effect could this have?
A
The reaction must speed up because any stronger binding lowers activation energy equally.
B
The reaction may slow because tight ground-state binding can make reaching the transition state less favorable.
C
The reaction's ΔG must become more negative because substrate binds tightly.
D
The enzyme must be consumed because it holds substrate longer.
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