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G Protein-Coupled Receptor Recognition
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AP Biology
APB.215 G Protein-Coupled Receptor Recognition
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Membrane vesicles are made with GPCRs oriented either right-side-out or inside-out. A hydrophilic ligand is added to the solution outside the vesicles. Which outcome supports a GPCR model?
A
Only inside-out vesicles respond because GPCR ligands always bind cytosolic loops first.
B
Neither orientation can respond because GPCRs do not span membranes.
C
Both orientations respond equally because hydrophilic ligands freely cross all membranes.
D
Only right-side-out vesicles respond because the ligand-binding domain must face the extracellular side while G proteins are on the cytosolic face.
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