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Gene Product Abundance and Phenotype
Grade Level
AP Biology
APB.323 Gene Product Abundance and Phenotype
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A receptor loses its ligand-binding domain but has an intracellular signaling domain that is locked in the active shape. Which prediction best explains the phenotype?
A
Downstream signaling may occur without ligand because the altered receptor function mimics activation.
B
Downstream signaling will stop because ligand binding is always required even for locked active receptors.
C
The receptor will be absent because active domains cannot be translated.
D
The phenotype will be normal because receptor abundance is unchanged.
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