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Mutations in Signaling Components
Grade Level
AP Biology
APB.222 Mutations in Signaling Components
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A G protein alpha subunit is normal, but its regulator that stimulates GTP hydrolysis is inactive. Which time-course pattern is most likely after a brief ligand pulse?
A
Downstream signaling rises and then declines more slowly than in wild type.
B
Downstream signaling never rises because the regulator is required for activation.
C
Downstream signaling falls immediately below basal levels after ligand is added.
D
Downstream signaling oscillates because GTP cannot bind the alpha subunit.
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