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Negative Feedback
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AP Biology
APB.225 Negative Feedback
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Chronic high cortisol can reduce the sensitivity of feedback receptors in some tissues. Which outcome would most directly weaken negative feedback?
A
High cortisol would completely eliminate the need for a sensor and always return instantly to normal.
B
High cortisol would be less able to suppress upstream CRH and ACTH release, so cortisol production could remain elevated longer.
C
Low cortisol would suppress CRH and ACTH more strongly, raising cortisol faster.
D
The feedback loop would become negative simply because receptor sensitivity is lower.
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